Clinical manifestations and severity of cow’s milk anaphylaxis in children

Methods In this study all children(<18 years old) with suspicious history of cow’s milk anaphylaxis who had been referred to IAARI(Immunology,Asthma and Allergy Research Institute)during 2005(JAN)—2010(SEP) were considered. A detailed questionnaire was fulfilled for each patient. A specific severity grading for anaphylaxis with five levels was also used. Skin Prick Test(SPT) with allergen extract(cow’s milk) was performed at least 4—6 weeks after patient’s last anaphylaxis attack. Cow’s milk specific IgE and total IgE level were measured by Immunocap system.Patients with clear history and one positive laboratory test and patients with both positive laboratory tests(SPT and cow’s milk specific IgE)were included.